Enclomiphene TherapyEnclomiphene Therapy
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From interest to treatment
A simple, guided process.
- 1
Tell us about yourself
Complete a short medical intake.
- 2
Physician review
A licensed clinician reviews your history and determines if treatment is appropriate.
- 3
Personalized plan
If appropriate, your clinician prescribes your treatment and dosage.
- 4
Delivered to you
Your medication is fulfilled through a licensed pharmacy.
- 5
Ongoing support
We monitor your progress and adjust as needed.
Who Might Consider Progesterone Therapy?
Hormonal changes during perimenopause and menopause can affect sleep, menstrual patterns, and overall function. Progesterone therapy plays an important role in women's hormonal health, particularly when combined with estrogen treatment. Understanding your symptoms, medical history, and individual hormone needs can help determine the most appropriate approach.
1
Taking Estrogen During Menopause
For women receiving estrogen therapy who still have a uterus, progesterone is often an important part of treatment. When appropriately prescribed, it helps protect the uterine lining, allowing women to manage menopause symptoms while addressing an important aspect of hormonal health.
2
Trouble Sleeping During Menopause
Difficulty falling asleep, waking frequently during the night, or feeling unrested can become more common during menopause. Oral progesterone has demonstrated benefits for certain aspects of sleep, making it a consideration when evaluating hormonal changes and nighttime symptoms.
3
Irregular or Missed Periods
As women approach menopause, menstrual cycles can become less predictable, with changes in timing, frequency, and flow. Progesterone plays an important role in regulating the uterine lining and may be prescribed in certain situations to help manage menstrual changes following a medical evaluation.
More Hormonal Health Treatments
Explore our other treatment options that may complement or offer alternatives to Progesterone Therapy.
Estrogen TherapyEstrogen Therapy
Replenishes estrogen to help relieve menopausal symptoms and support hormonal health.
Testosterone TherapyTestosterone Therapy
Hormone replacement therapy for men with low testosterone levels.
Explore Our Programs
Discover more specialized treatments and services offered at Fountain
Frequently Asked Questions
Everything you need to know about Progesterone Therapy treatment
What is progesterone, and why is it used in hormone therapy?
Progesterone is a hormone naturally produced by the body and is commonly used as part of hormone therapy during perimenopause and menopause. When systemic estrogen is prescribed for someone who has not had a hysterectomy, progesterone is generally included to help protect the uterine lining. It may also affect symptoms such as sleep and mood, depending on the individual. At Fountain, progesterone is considered as part of the broader hormone treatment plan rather than as an isolated therapy.
Can progesterone help with sleep?
Some patients find that progesterone has a calming or sedating effect and notice improved sleep after starting treatment. That does not mean progesterone is the right sleep treatment for everyone. Poor sleep can also be caused by hot flashes, anxiety, stress, sleep apnea, medications, alcohol, or other health conditions. If sleep remains disrupted, Fountain looks for other contributing factors rather than simply increasing progesterone.
Why does progesterone make some people sleepy?
Progesterone can have calming effects on the brain, which is why some people feel sleepy after taking it. For many patients, taking it in the evening works well. Others may experience next-day fatigue or grogginess. If that happens consistently, your clinician can review the timing, dose, and treatment plan rather than assuming it is something you simply have to tolerate.
What side effects can progesterone cause?
Possible side effects can include sleepiness, dizziness, breast tenderness, bloating, headache, mood changes, or changes in bleeding patterns. If you experience significant mood changes, unexpected bleeding, or symptoms that are persistent or bothersome, let your clinician know so the treatment plan can be reassessed.
How is the right progesterone regimen determined?
The right progesterone regimen depends on why it is being prescribed, whether you are also taking estrogen, your stage of perimenopause or menopause, your symptoms, and your overall health history. Some patients take progesterone every day, while others may use it on a cyclical schedule. Fountain considers progesterone alongside the rest of your hormone therapy so the treatment plan works together as a whole.
Clinically reviewed by
Last reviewed: October 2026
Dr. Doreen Zarfati is Chief Medical Officer at Fountain Health NYC and a double board-certified psychiatrist. Her work spans mental health, longevity, metabolism and sexual health, with a particular interest in how biological and clinical factors can influence psychiatric symptoms and treatment response. At Fountain, Dr. Zarfati provides clinical oversight of Fountain’s care models, reviewing and approving them for clinical use and guiding how they are applied in patient care. Her work in IV ketamine focuses on neuroplasticity, emotional processing and the thoughtful integration of emerging treatments into structured clinical care. Her approach is individualized, collaborative and grounded in measurable response, with treatment evolving as the patient’s clinical picture changes.
Looking for more answers?
Explore our full FAQ library for common questions about mental health, ketamine, weight management, hormones, sleep, nutrition, billing, and more.
Wondering if Progesterone Is Right for You?
Important Safety Information
Compounded medications are available only to patients who are evaluated by a licensed healthcare provider and receive a prescription when medically appropriate. Prescriptions for compounded medications are filled and dispensed by a licensed compounding pharmacy. Compounded medications are not FDA-approved, and the FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed. Individual results may vary. Product images are for illustrative purposes only and may not reflect the actual medication, packaging, vial, or dosage dispensed.